Module 6: Structure-Function Relationships



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Different categories of biological information can be analyzed in the context of relationships between structures of molecules and their corresponding functions in biological systems.

  • Focus on protein structure-function studies: In this module, we will concentrate on protein structure-function relationships since major metabolic activities in almost all biological systems depend on macromolecular proteins (structural proteins, enzymes, antibodies etc.,)

  • Open reading frames (ORF) in test DNA sequences: We will discuss identification of ORF's in the context that DNA sequence correlates linearly with amino acid sequence within any DNA carrying coding information.

  • Chromosomal structures: There are a variety of structures in chromosomes playing a role in chromosomal duplication. We will discuss structures such as centromeres and telomeres to look at how their sequences affect their function.

  • DNA binding proteins: There are a large number of proteins classified as "DNA-binding" for a variety of functions, such as transcriptional activation/inhibition, DNA replication (gyrases, polymerases, ligases etc.,), DNA stabilization (histones), and etc. We will look at some structures containing these proteins. In general, due to the limited computational analysis of these molecules, there are not many databases where they are stored.

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