Module 6: Structure-Function Relationships

 

Chromosomal Structures

Protein modeling module 6 contents Exercise 6 back to the index of modules


  • A good source for nucleic acid structures and related functions can be found at the Nucleic Acid Database Project (http://ndbserver.rutgers.edu/NDB/index.html)

  • Histone binding sites: DNA sequences in chromosomes which interact with histones have been analyzed as part of structure-function studies (Figure of Histones Binding to DNA).

  • Centromeres: These structures are found in the middle of chromosomes, generally separating the long and short arms. They are highly enriched with repetitive DNA sequences. A DNA-binding protein with a helix-turn-helix loop binds to human centromeric sequence (Figure of Centromere Binding Protein).

  • Telomeres: These structures at the tips of chromosomes seem to be cytosine rich (Figure of Intramolecular Folding in a Telomere). They have been implicated in the process of cellular aging. It has been hypothesized that as cells age (that is go through more and more cell divisions) the telomeres get progressively shorter. An example of a protein binding to the telomeric structure is shown here (Figure of a telomere binding protein complexed to DNA).


Protein modeling module 6 contents Exercise 6 back to the index of modules

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SWBIC 2001