Module 7: Molecular Computing with RNA Sequences

 

Introduction

Back to Module 7 module 7 contents transcriptional control back to the index of modules


In this module, we will discuss computational tools employed in the control of transcription (DNA to RNA) and the analysis of RNA structures.
  • Regulation of gene expression during transcription: Control of DNA transcription is in part regulated using sequences such as promoters, enhancers, silencers, and attenuators. Also, a large number of transcription factors (enzymes and other proteins) that interact with these sites have been identified and classified.

  • Sequences responsible for RNA stability: Secondary, tertiary and quarternary structures of RNA are quite important in their stability as stand-alone molecules (eg., tRNA) or as complexes with other nucleic acids or proteins (eg., ribosomes).

  • RNA splicing control elements: Consensus sequences in nascent RNA structures have been identified as sites at which splicing occurs to form the shortened messenger RNA (mRNA) molecules. Also, alternative splicing of primary transcripts has been observed in a variety of organisms as a common mechanism for gene regulation.

  • Translational control sequences: 5' and 3' untranslated regions of RNA molecules carry sequences which regulate the conversion of mRNA to protein. Most of them play a role in lengthening or shortening the half-life of the mRNA molecule.


Back to Module 7 module 7 contents transcriptional control back to the index of modules

| Return to SWBIC home |

The Southwest Biotechnology and Informatics Center WWW server is located at "http://www.swbic.org/".
Please send comments and suggestions to: [email protected]
SWBIC 2001