Module 7: Molecular Computing with RNA Sequences
|In this module, we will discuss computational tools employed in the control of transcription (DNA to RNA) and the analysis
of RNA structures.
- Regulation of gene expression during transcription: Control of DNA transcription is in part regulated using
sequences such as promoters, enhancers, silencers, and attenuators. Also, a large number of transcription factors
(enzymes and other proteins) that interact with these sites have been identified and classified.
- Sequences responsible for RNA stability: Secondary, tertiary and quarternary structures of RNA are quite
important in their stability as stand-alone molecules (eg., tRNA) or as complexes with other nucleic acids or
proteins (eg., ribosomes).
- RNA splicing control elements: Consensus sequences in nascent RNA structures have been identified as sites at
which splicing occurs to form the shortened messenger RNA (mRNA) molecules. Also, alternative splicing of primary
transcripts has been observed in a variety of organisms as a common mechanism for gene regulation.
- Translational control sequences: 5' and 3' untranslated regions of RNA molecules carry sequences which regulate
the conversion of mRNA to protein. Most of them play a role in lengthening or shortening the half-life of the mRNA