Module 2: Storage, Retrieval and Manipulation of DNA Information (General Themes)

 

How to deposit and retrieve DNA sequences?

Where is the DNA information stored? module 2 contents How to manipulate DNA sequences for various applications? back to the index of modules


There are different ports of entry to access DNA information (See Module 3 for a list and more detailed discussion.) already stored in various databases. Let us assume that a research group has sequenced a new segment of DNA from an unidentified clone or from a cloned gene. Then, the next step is to check if there is any DNA sequence "out there" that resembles the newly sequenced DNA. If there is any sequence similarity to a database sequence(s), it would be interesting to find out the percentage of similarity (or homology) between the 2 sequences. The research group will most likely submit the test sequence to a database so that other researchers can retrieve and manipulate the new data as part of the database.

Since DNA sequences are being submitted by research laboratories from all over the world, there is a lack of uniformity in the submission & stored data formats and in the accessing tools available to different laboratories. Hence, one has to be aware of the submission format requirements of different databases and their output formats when accessing results from database search queries. We will cover these topics in much more detail as we get into later modules.


Where is the DNA information stored? module 2 contents How to manipulate DNA sequences for various applications? back to the index of modules

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SWBIC 2001